IGFBP3

Across TCGA patient cohorts, IGFBP3 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGFBP3-associated genes across cancer lineages are Cyclin-E2, JNK2, and MEK1. Each is linked with IGFBP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGFBP3-to-partner and partner-to-IGFBP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E2 grouped by IGFBP3-low versus IGFBP3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGFBP3→partner) and Y-score (partner→IGFBP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-E2 →	+0.179	+2.817	.034	.036	3	2
UCEC	JNK2 →	+0.212	+2.321	.033	.035	3	1
UCEC	MEK1 →	+0.565	+3.459	.002	.005	3	1
UCEC	Notch1 →	+0.240	+3.459	<.001	.005	3	1
UCEC	PKC-b-II_pS660 →	-0.402	-3.459	.003	.005	3	1
UCEC	Rab25 →	-0.560	-2.321	<.001	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Cyclin-E2 by IGFBP3 expression — UCEC

Explore this box plot interactively →