IGFBP3

Across TCGA cell cohorts, IGFBP3 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IGFBP3-associated genes across cancer lineages are MAGEB4, SARAF, and UBE2Q2. Each is linked with IGFBP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGFBP3-to-partner and partner-to-IGFBP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB4 grouped by IGFBP3-low versus IGFBP3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGFBP3→partner) and Y-score (partner→IGFBP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAGEB4 →	+0.011	+3.415	<.001	.001	3	1
LARGE_INTESTINE	SARAF →	+0.747	+3.125	.003	.008	3	1
LARGE_INTESTINE	UBE2Q2 →	+1.025	+3.215	<.001	.009	3	1
LARGE_INTESTINE	PDCL2 →	+0.197	+3.584	<.001	.003	3	1
LARGE_INTESTINE	CX3CR1 →	+0.145	+3.215	<.001	.009	3	1
LARGE_INTESTINE	S100G →	+0.922	+3.009	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

MAGEB4 by IGFBP3 expression — LARGE_INTESTINE

Explore this box plot interactively →