IGFBP2

Across TCGA pan-cancer cohorts, IGFBP2 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of IGFBP2’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGFBP2 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types IGFBP2 is over-expressed in tumor, although a few such as COAD and PDAC show the opposite, repressed pattern.

COAD, PDAC, and LSCC are the cancer types where IGFBP2 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGFBP2 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	All	−0.756	<.001	11	view →
PDAC	Female	II,III,IV	−1.479	<.001	8	view →
LSCC	All	III,IV	+1.468	<.001	8	view →
CCRCC	Male	III,IV	−0.984	<.001	8	view →
LUAD	All	All	+0.456	<.001	6	view →
OV	All	All	+0.823	.036	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

IGFBP2–COAD

Open the COAD breakdown →