IGFBP2

Across TCGA pan-cancer cohorts, IGFBP2 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated IGFBP2 data layer compared with 2 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher IGFBP2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated IGFBP2 expression acts as an unfavorable survival marker, although some lineages such as PAAD and DLBC show a favorable association.

UVM, KIRP, and LGG are the cancer types where IGFBP2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.386	0.785	<.001	124	view →
KIRP	OS	Quartile	All	0.756	0.951	<.001	106	view →
LGG	OS	Median	All	0.700	0.923	<.001	54	view →
UCS	DFS	Median	IV	0.367	0.952	.001	36	view →
PAAD	OS	Median	All	0.600	0.311	.002	30	view →
MESO	OS	Median	III,IV	0.434	0.698	<.001	29	view →
DLBC	DFS	Quartile	All	1.000	0.426	.019	19	view →
UCEC	OS	Quartile	II,III,IV	0.780	0.925	.016	18	view →
KIRC	DFS	Tertile	II,III,IV	0.442	0.635	.017	17	view →
LUSC	DFS	Quartile	II,III,IV	0.741	0.302	.011	16	view →
THCA	DFS	Median	All	0.879	0.773	.003	16	view →
ACC	DFS	Median	All	0.269	0.772	.002	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

IGFBP2–UVM (DFS)

Open the UVM breakdown →