IGFBP2

Across TCGA patient cohorts, IGFBP2 protein abundance is significantly associated with the RNA expression of many other genes, with 12,687 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible IGFBP2-associated genes across cancer lineages are CTLA4, TAP2, and CADM4. Each is linked with IGFBP2 in more than 6 cancer types. Because this analysis shows association rather than direction, both IGFBP2-to-partner and partner-to-IGFBP2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGFBP2 versus CTLA4 in HNSC, with a Pearson correlation of -0.29.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGFBP2→partner) and Y-score (partner→IGFBP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CTLA4 →	-1.097	-0.596	<.001	.005	3	7
HNSC	TAP2 →	-0.754	-0.719	<.001	<.001	3	6
HNSC	CADM4 →	+1.081	+0.899	<.001	<.001	3	5
OV	IGFBP5 →	+1.976	+0.749	<.001	.001	3	5
GBM	SUSD3 →	-0.804	-0.766	.004	.001	3	5
HNSC	STAT1 →	-0.927	-0.737	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,687 associations by consensus.

IGFBP2 vs CTLA4 — HNSC

Explore this scatter interactively →