IGFBP2

Across TCGA patient cohorts, IGFBP2 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGFBP2-associated genes across cancer lineages are JNK2, MEK1, and MSH2. Each is linked with IGFBP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGFBP2-to-partner and partner-to-IGFBP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by IGFBP2-low versus IGFBP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGFBP2→partner) and Y-score (partner→IGFBP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.189	+2.817	.035	.036	3	1
UCEC	MEK1 →	+0.372	+2.459	.024	.019	3	1
UCEC	MSH2 →	-0.320	-3.143	.002	.018	3	1
UCEC	MSH6 →	-0.480	-2.000	.001	.032	3	1
UCEC	PREX1 →	-0.262	-3.169	.034	.018	3	1
UCEC	Annexin-1 →	+0.531	+3.019	.025	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

JNK2 by IGFBP2 expression — UCEC

Explore this box plot interactively →