IGFBP2

Across TCGA cell cohorts, IGFBP2 mutation is significantly associated with the RNA expression of many other genes, with 38 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible IGFBP2-associated genes across cancer lineages are PRDM12, REG1B, and RNF148. Each is linked with IGFBP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGFBP2-to-partner and partner-to-IGFBP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRDM12 grouped by IGFBP2-low versus IGFBP2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGFBP2→partner) and Y-score (partner→IGFBP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PRDM12 →	+0.247	+3.215	<.001	.009	3	1
LARGE_INTESTINE	REG1B →	+2.555	+2.518	<.001	.006	3	1
LARGE_INTESTINE	RNF148 →	+0.319	+3.215	<.001	.009	3	1
LUNG_NSCLC_LUAD	CST9L →	+0.022	+4.947	.001	.001	3	1
LUNG_NSCLC_LUAD	OOSP4B →	+0.017	+5.266	<.001	.001	3	1
BLOOD_Leukemia	ITIH6 →	+0.019	+3.754	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

PRDM12 by IGFBP2 expression — LARGE_INTESTINE

Explore this box plot interactively →