IGFBP1

Across TCGA patient cohorts, IGFBP1 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGFBP1-associated genes across cancer lineages are ASNS, C-Raf, and FoxM1. Each is linked with IGFBP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGFBP1-to-partner and partner-to-IGFBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by IGFBP1-low versus IGFBP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGFBP1→partner) and Y-score (partner→IGFBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.568	+2.000	<.001	.030	3	2
UCEC	C-Raf →	+0.171	+1.700	.004	.044	3	2
UCEC	FoxM1 →	+0.255	+2.222	.020	.011	3	1
UCEC	Notch1 →	+0.191	+3.009	.001	.019	3	1
UCEC	p27_pT198 →	+0.090	+2.222	.046	.011	3	1
UCEC	PCNA →	+0.216	+1.700	.018	.044	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

ASNS by IGFBP1 expression — UCEC

Explore this box plot interactively →