IGFBP1

Across TCGA cell cohorts, IGFBP1 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible IGFBP1-associated genes across cancer lineages are TSPY2, BPY2, and BPY2B. Each is linked with IGFBP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGFBP1-to-partner and partner-to-IGFBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TSPY2 grouped by IGFBP1-low versus IGFBP1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGFBP1→partner) and Y-score (partner→IGFBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TSPY2 →	+0.612	+4.887	.002	.009	3	1
LUNG_NSCLC_LUAD	BPY2 →	+0.006	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	BPY2B →	+0.006	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	BPY2C →	+0.006	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	SSX7 →	+0.022	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	LRIT2 →	+0.022	+4.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

TSPY2 by IGFBP1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →