IGFALS

Across TCGA patient cohorts, IGFALS mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. COAD shows the largest number of these associations.

The most reproducible IGFALS-associated genes across cancer lineages are mTOR, PCNA, and ATM. Each is linked with IGFALS in more than 2 cancer types. Because this analysis shows association rather than direction, both IGFALS-to-partner and partner-to-IGFALS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR grouped by IGFALS-low versus IGFALS-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGFALS→partner) and Y-score (partner→IGFALS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	mTOR →	-0.262	-3.000	.003	.035	3	2
UCEC	PCNA →	+0.328	+3.000	.008	.036	2	3
UCEC	ATM →	-0.715	-3.000	.006	.037	3	2
COAD	INPP4B →	-0.478	-2.450	.003	.020	3	1
COAD	PAI-1 →	+0.698	+3.017	.006	.017	3	1
COAD	PRAS40_pT246 →	-0.171	-2.450	.019	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

mTOR by IGFALS expression — COAD

Explore this box plot interactively →