IGFALS

Across TCGA pan-cancer cohorts, IGFALS RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of IGFALS’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where IGFALS RNA is repressed in tumor relative to normal tissue. In most cancer types IGFALS is over-expressed in tumor, although a few such as KIRC and LUAD show the opposite, repressed pattern.

KIRC, LUAD, and KICH are the cancer types where IGFALS tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGFALS RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	−0.880	<.001	12	view →
LUAD	Female	III,IV	−1.883	<.001	11	view →
KICH	All	IV	−1.207	<.001	11	view →
LIHC	Male	II,III,IV	−5.016	<.001	9	view →
LUSC	Female	II,III,IV	−2.284	<.001	9	view →
KIRP	Female	II,III,IV	−1.382	<.001	8	view →
BRCA	All	All	+0.843	<.001	6	view →
CHOL	All	All	−2.686	<.001	2	view →
BLCA	All	IV	−0.118	.036	2	view →
PRAD	All	All	−0.097	.048	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

IGFALS–KIRC

Open the KIRC breakdown →