IGFALS

Across TCGA cell cohorts, IGFALS RNA expression is significantly associated with the go_rna of many other GO terms, with 3,419 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible IGFALS-associated GO terms across cancer lineages are Negative regulation of myoblast fusion, Cilium movement involved in cell motility, and Negative regulation of translational initiation. Each is linked with IGFALS in more than 12 cancer types. Because this analysis shows association rather than direction, both IGFALS-to-partner and partner-to-IGFALS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of myoblast fusion grouped by IGFALS-low versus IGFALS-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGFALS→partner) and Y-score (partner→IGFALS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Negative regulation of myoblast fusion →	+0.132	+0.264	<.001	<.001	3	13
OESOPHAGUS	Cilium movement involved in cell motility →	-0.094	-0.300	.001	.009	3	13
BONE	Negative regulation of translational initiation →	+0.114	+0.163	.002	.004	3	13
UPPER_AERODIGESTIVE_TRACT	Protein polyubiquitination →	+0.049	+0.210	<.001	<.001	3	12
OESOPHAGUS	Regulation of syncytium formation by plasma membrane fusion →	+0.117	+0.331	<.001	.003	3	12
UPPER_AERODIGESTIVE_TRACT	mRNA splice site recognition →	+0.109	+0.188	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,419 associations by consensus.

Negative regulation of myoblast fusion by IGFALS expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →