IGFALS

Across TCGA cell cohorts, IGFALS mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible IGFALS-associated genes across cancer lineages are BTNL2, TCF21, and PAX1. Each is linked with IGFALS in more than 1 cancer types. Because this analysis shows association rather than direction, both IGFALS-to-partner and partner-to-IGFALS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BTNL2 grouped by IGFALS-low versus IGFALS-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGFALS→partner) and Y-score (partner→IGFALS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	BTNL2 →	+0.031	+4.169	.001	.008	3	1
BLOOD_Leukemia	TCF21 →	+0.008	+3.705	.002	.007	3	1
BLOOD_Leukemia	PAX1 →	+0.046	+4.060	<.001	.003	3	1
BLOOD_Leukemia	RHCG →	+0.088	+3.729	.002	.009	3	1
BLOOD_Leukemia	FAM83B →	+0.119	+4.234	.003	.003	3	1
BLOOD_Leukemia	GUCA2A →	+0.031	+4.384	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

BTNL2 by IGFALS expression — CNS

Explore this box plot interactively →