Across TCGA patient cohorts, IGF2R protein abundance is significantly associated with the RNA expression of many other genes, with 11,328 significant associations in total. GBM shows the largest number of these associations.

The most reproducible IGF2R-associated genes across cancer lineages are TCP1, ZNF181, and LRRC59. Each is linked with IGF2R in more than 5 cancer types. Because this analysis shows association rather than direction, both IGF2R-to-partner and partner-to-IGF2R results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGF2R→partner) and Y-score (partner→IGF2R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TCP1 →	+0.676	+0.429	<.001	<.001	3	6
OV	ZNF181 →	-0.454	-0.272	.007	.009	3	6
OV	LRRC59 →	+0.542	+0.232	<.001	<.001	3	5
CCRCC	ATF5 →	+0.694	+0.300	<.001	<.001	3	5
OV	WTAP →	+0.578	+0.381	<.001	<.001	3	5
CCRCC	PARD3B →	-0.602	-0.324	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,328 associations by consensus.

Exploration

IGF2R survival (RNA) · tumor vs normal (RNA) · all IGF2R data types