IGF2BP3

Across TCGA patient cohorts, IGF2BP3 mutation is significantly associated with the RNA expression of many other genes, with 2,714 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGF2BP3-associated genes across cancer lineages are RN7SL134P, RNVU1-26, and RNA5SP149. Each is linked with IGF2BP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGF2BP3-to-partner and partner-to-IGF2BP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL134P grouped by IGF2BP3-low versus IGF2BP3-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGF2BP3→partner) and Y-score (partner→IGF2BP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RN7SL134P →	+0.142	+3.874	<.001	.006	3	2
CESC	RNVU1-26 →	+0.522	+3.705	<.001	.008	3	2
SKCM	RNA5SP149 →	+0.180	+3.292	<.001	.001	3	2
UCEC	TMEM219 →	+0.334	+3.087	<.001	<.001	3	2
UCEC	XKR8 →	+0.232	+2.249	.003	.001	3	2
UCEC	MFSD12 →	+0.409	+2.354	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,714 associations by consensus.

RN7SL134P by IGF2BP3 expression — CESC

Explore this box plot interactively →