IGF2BP3

Across TCGA pan-cancer cohorts, IGF2BP3 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated IGF2BP3 data layer compared with 5 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher IGF2BP3 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated IGF2BP3 expression acts as an unfavorable survival marker, although some lineages such as SCLC and UCS show a favorable association.

KIRP, KIRC, and MESO are the cancer types where IGF2BP3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.522	0.822	<.001	174	view →
KIRC	OS	Median	All	0.523	0.724	<.001	126	view →
MESO	OS	Median	All	0.260	0.515	<.001	117	view →
UVM	DFS	Median	All	0.517	0.915	<.001	97	view →
BLCA	DFS	Tertile	III,IV	0.282	0.610	<.001	79	view →
COAD	OS	Median	All	0.423	0.883	<.001	55	view →
LGG	OS	Median	All	0.688	0.929	<.001	54	view →
LIHC	DFS	Median	All	0.295	0.533	<.001	49	view →
SCLC	OS	Tertile	II,III,IV	0.600	0.188	.004	45	view →
PAAD	OS	Quartile	All	0.264	0.642	<.001	43	view →
UCS	DFS	Median	IV	0.952	0.367	.001	42	view →
ACC	DFS	Quartile	All	0.418	0.804	.001	37	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

IGF2BP3–KIRP (OS)

Open the KIRP breakdown →