IGF2BP3

Across TCGA patient cohorts, IGF2BP3 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGF2BP3-associated genes across cancer lineages are TFRC, JNK2, and AMPK_pT172. Each is linked with IGF2BP3 in more than 2 cancer types. Because this analysis shows association rather than direction, both IGF2BP3-to-partner and partner-to-IGF2BP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by IGF2BP3-low versus IGF2BP3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGF2BP3→partner) and Y-score (partner→IGF2BP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.354	+1.874	.043	.049	3	3
UCEC	JNK2 →	+0.194	+1.727	.003	.023	3	2
UCEC	AMPK_pT172 →	+0.325	+1.678	.016	.021	3	2
UCEC	CD49b →	-0.270	-2.571	.003	.010	3	2
UCEC	Cyclin-B1 →	+0.490	+1.700	.008	.040	3	2
UCEC	14-3-3_beta →	-0.106	-2.880	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

TFRC by IGF2BP3 expression — UCEC

Explore this box plot interactively →