IGF2BP3

Across TCGA cell cohorts, IGF2BP3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,522 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible IGF2BP3-associated GO terms across cancer lineages are Regulation of transferase activity, Protein autoubiquitination, and Negative regulation of post-translational protein modification. Each is linked with IGF2BP3 in more than 9 cancer types. Because this analysis shows association rather than direction, both IGF2BP3-to-partner and partner-to-IGF2BP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of transferase activity grouped by IGF2BP3-low versus IGF2BP3-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGF2BP3→partner) and Y-score (partner→IGF2BP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Regulation of transferase activity →	+0.033	+1.599	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Protein autoubiquitination →	+0.061	+1.042	<.001	.003	2	9
BONE	Negative regulation of post-translational protein modification →	+0.084	+1.611	<.001	.005	3	8
BREAST	Positive regulation of focal adhesion assembly →	+0.170	+2.777	<.001	<.001	3	8
BREAST	Pore complex assembly →	+0.106	+2.057	<.001	<.001	3	8
BLOOD_Lymphoma	DNA-templated transcription initiation →	+0.057	+2.030	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,522 associations by consensus.

Regulation of transferase activity by IGF2BP3 expression — LARGE_INTESTINE

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