IGF2BP2

Across TCGA patient cohorts, IGF2BP2 protein abundance is significantly associated with the RNA expression of many other genes, with 21,565 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IGF2BP2-associated genes across cancer lineages are HMGA2, IGF2BP2-AS1, and HMGA1. Each is linked with IGF2BP2 in more than 7 cancer types. Because this analysis shows association rather than direction, both IGF2BP2-to-partner and partner-to-IGF2BP2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGF2BP2 versus HMGA2 in LSCC, with a Pearson correlation of 0.66.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGF2BP2→partner) and Y-score (partner→IGF2BP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	HMGA2 →	+1.538	+1.359	<.001	<.001	3	8
UCEC	IGF2BP2-AS1 →	+2.441	+1.478	<.001	<.001	3	8
LUAD	HMGA1 →	+1.093	+0.583	<.001	<.001	3	7
GBM	HMGA2-AS1 →	+1.409	+0.786	<.001	<.001	3	7
GBM	RPSAP52 →	+1.119	+0.872	<.001	<.001	3	7
UCEC	MIR548AQ →	+3.490	+1.016	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 21,565 associations by consensus.

IGF2BP2 vs HMGA2 — LSCC

Explore this scatter interactively →