IGF2BP2-AS1

Across TCGA pan-cancer cohorts, IGF2BP2-AS1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of IGF2BP2-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where IGF2BP2-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types IGF2BP2-AS1 is over-expressed in tumor, although a few such as KIRP and KIRC show the opposite, repressed pattern.

HNSC, KIRP, and KIRC are the cancer types where IGF2BP2-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGF2BP2-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.446	<.001	12	view →
KIRP	All	III,IV	−0.226	<.001	8	view →
KIRC	Male	All	−0.170	<.001	8	view →
LUSC	Male	All	+0.357	<.001	7	view →
KICH	All	All	−0.128	<.001	5	view →
STAD	All	All	+0.253	.002	4	view →
LIHC	Male	All	+0.239	<.001	4	view →
READ	Male	All	−0.110	.021	4	view →
PAAD	Male	All	+0.145	.028	2	view →
BRCA	All	III,IV	−0.040	<.001	2	view →
ESCA	Female	All	+0.630	.034	1	view →
CHOL	Male	All	+0.091	.029	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

IGF2BP2-AS1–HNSC

Open the HNSC breakdown →