IGF2BP1

Across TCGA cell cohorts, IGF2BP1 mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IGF2BP1-associated genes across cancer lineages are FCN2, TXNDC8, and OCIAD1. Each is linked with IGF2BP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGF2BP1-to-partner and partner-to-IGF2BP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FCN2 grouped by IGF2BP1-low versus IGF2BP1-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGF2BP1→partner) and Y-score (partner→IGF2BP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	FCN2 →	+0.033	+5.087	<.001	.004	3	1
URINARY_TRACT	TXNDC8 →	+0.013	+5.087	<.001	.004	3	1
LARGE_INTESTINE	OCIAD1 →	+0.480	+3.125	.004	.008	3	1
LARGE_INTESTINE	CNTN3 →	+0.341	+2.444	<.001	.008	3	1
LARGE_INTESTINE	GFRA4 →	+0.021	+3.023	<.001	.002	3	1
LARGE_INTESTINE	NARS1 →	+0.979	+3.067	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

FCN2 by IGF2BP1 expression — URINARY_TRACT

Explore this box plot interactively →