IGF2BP1

Across TCGA pan-cancer cohorts, IGF2BP1 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated IGF2BP1 data layer compared with 3 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher IGF2BP1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated IGF2BP1 expression acts as an unfavorable survival marker, although some lineages such as UCS and SCLC show a favorable association.

MESO, ACC, and THCA are the cancer types where IGF2BP1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.419	0.654	<.001	114	view →
ACC	OS	Median	All	0.446	0.759	<.001	110	view →
THCA	DFS	Median	All	0.856	0.930	.001	88	view →
UCS	OS	Median	II,III,IV	0.786	0.389	<.001	84	view →
LUAD	DFS	Tertile	All	0.556	0.715	<.001	82	view →
UCEC	OS	Median	All	0.581	0.836	<.001	78	view →
KICH	DFS	Tertile	All	0.636	0.972	.001	67	view →
BRCA	OS	Median	II,III,IV	0.880	0.941	.001	61	view →
KIRC	DFS	Tertile	All	0.563	0.756	.001	54	view →
LGG	DFS	Tertile	All	0.322	0.539	<.001	50	view →
LIHC	OS	Quartile	All	0.680	0.883	<.001	48	view →
UVM	DFS	Quartile	All	0.403	0.717	.002	36	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

IGF2BP1–MESO (OS)

Open the MESO breakdown →