IGF2

Across TCGA patient cohorts, IGF2 protein abundance is significantly associated with the RNA expression of many other genes, with 1,009 significant associations in total. GBM shows the largest number of these associations.

The most reproducible IGF2-associated genes across cancer lineages are EHD4, DMAC2, and CTNNAL1. Each is linked with IGF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGF2-to-partner and partner-to-IGF2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGF2 versus EHD4 in HNSC, with a Pearson correlation of -0.81.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGF2→partner) and Y-score (partner→IGF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	EHD4 →	-1.042	-0.849	.001	<.001	3	1
HNSC	DMAC2 →	-0.450	-0.783	<.001	.004	3	1
HNSC	CTNNAL1 →	-1.109	-0.780	.009	.004	3	1
HNSC	FLVCR2 →	-1.344	-0.849	.001	<.001	3	1
HNSC	NR2C1 →	-0.773	-0.783	.005	.004	3	1
HNSC	PLBD1 →	-1.423	-0.780	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,009 associations by consensus.

IGF2 vs EHD4 — HNSC

Explore this scatter interactively →