IGF2

Across TCGA pan-cancer cohorts, IGF2 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated IGF2 data layer compared with 4 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher IGF2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated IGF2 expression acts as an unfavorable survival marker, although some lineages such as UCS and UCEC show a favorable association.

KIRP, UCS, and UVM are the cancer types where IGF2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Tertile	All	0.486	0.760	<.001	93	view →
UCS	OS	Median	III,IV	0.768	0.385	.003	76	view →
UVM	OS	Tertile	All	0.478	1.000	<.001	74	view →
MESO	OS	Tertile	II,III,IV	0.304	0.610	.001	73	view →
OV	OS	Median	All	0.803	0.878	.005	44	view →
SKCM	DFS	Quartile	III,IV	0.335	0.588	.006	29	view →
CESC	DFS	Quartile	All	0.730	0.846	.011	20	view →
UCEC	DFS	Median	All	0.924	0.868	.010	16	view →
LIHC	OS	Tertile	All	0.743	0.591	.006	12	view →
CHOL	OS	Median	IV	0.208	0.948	.010	12	view →
STAD	OS	Quartile	III,IV	0.219	0.566	.019	10	view →
PAAD	DFS	Tertile	II,III,IV	0.434	0.267	.005	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

IGF2–KIRP (DFS)

Open the KIRP breakdown →