IGF2

Across TCGA patient cohorts, IGF2 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGF2-associated genes across cancer lineages are PDCD4, PCNA, and STAT3_pY705. Each is linked with IGF2 in more than 2 cancer types. Because this analysis shows association rather than direction, both IGF2-to-partner and partner-to-IGF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by IGF2-low versus IGF2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGF2→partner) and Y-score (partner→IGF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.511	-2.312	.010	.034	3	3
UCEC	PCNA →	+0.263	+1.700	.004	.044	3	2
UCEC	STAT3_pY705 →	-0.400	-2.222	<.001	.011	3	2
UCEC	4E-BP1 →	+0.298	+3.321	.009	.009	3	2
UCEC	EGFR →	-0.169	-2.973	.012	.035	3	1
UCEC	eIF4E →	+0.191	+2.906	.032	.001	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

PDCD4 by IGF2 expression — UCEC

Explore this box plot interactively →