IGF2

Across TCGA cell cohorts, IGF2 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IGF2-associated genes across cancer lineages are NPHS2, MSGN1, and TFDP3. Each is linked with IGF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGF2-to-partner and partner-to-IGF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NPHS2 grouped by IGF2-low versus IGF2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGF2→partner) and Y-score (partner→IGF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NPHS2 →	+0.067	+3.766	.009	.004	3	1
LARGE_INTESTINE	MSGN1 →	+0.095	+4.345	<.001	<.001	3	1
LARGE_INTESTINE	TFDP3 →	+0.020	+3.196	.001	.007	3	1
LARGE_INTESTINE	TAFA1 →	+0.281	+5.009	<.001	<.001	3	1
LARGE_INTESTINE	BPY2 →	+0.015	+4.022	<.001	.006	3	1
LARGE_INTESTINE	BPY2B →	+0.015	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

NPHS2 by IGF2 expression — LARGE_INTESTINE

Explore this box plot interactively →