IGF2-AS

Across TCGA pan-cancer cohorts, IGF2-AS RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated IGF2-AS data layer compared with 4 for mass-spec protein.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher IGF2-AS RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGF2-AS expression acts as an unfavorable survival marker, although some lineages such as UCS and LIHC show a favorable association.

UCS, MESO, and OV are the cancer types where IGF2-AS RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	DFS	Tertile	II,III,IV	0.735	0.274	.004	58	view →
MESO	OS	Median	All	0.295	0.472	.005	54	view →
OV	OS	Median	II,III,IV	0.805	0.879	.005	42	view →
STAD	OS	Median	All	0.320	0.494	.005	23	view →
LUSC	OS	Median	III,IV	0.237	0.547	.001	17	view →
THCA	OS	Quartile	II,III,IV	0.782	0.987	.011	16	view →
BLCA	OS	Quartile	IV	0.156	0.577	.013	15	view →
LIHC	DFS	Median	All	0.503	0.375	.019	11	view →
KIRC	DFS	Quartile	IV	0.415	0.678	.012	8	view →
LGG	DFS	Quartile	All	0.321	0.496	.013	7	view →
CHOL	DFS	Median	All	0.238	0.644	.041	6	view →
CESC	DFS	Median	IV	0.432	0.093	.042	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

IGF2-AS–UCS (DFS)

Open the UCS breakdown →