IGF2-AS

Across TCGA pan-cancer cohorts, IGF2-AS RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of IGF2-AS’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where IGF2-AS RNA is more highly expressed in tumor relative to normal tissue. In most cancer types IGF2-AS is over-expressed in tumor, although a few such as UCEC and KICH show the opposite, repressed pattern.

HNSC, UCEC, and KICH are the cancer types where IGF2-AS tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGF2-AS RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	II,III,IV	+0.241	<.001	10	view →
UCEC	All	II,III,IV	−0.882	<.001	8	view →
KICH	All	All	−0.565	<.001	7	view →
BLCA	Male	All	+1.136	.004	6	view →
KIRP	All	All	−0.191	<.001	6	view →
KIRC	All	II,III,IV	−0.239	<.001	5	view →
BRCA	Female	All	−0.184	<.001	4	view →
LUAD	All	All	+0.085	.007	4	view →
COAD	Male	II,III,IV	+0.068	.012	4	view →
LUSC	All	All	+0.208	.011	3	view →
LIHC	Female	II,III,IV	+0.940	.043	2	view →
PRAD	All	All	−0.111	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

IGF2-AS–HNSC

Open the HNSC breakdown →