IGF1R

Across TCGA patient cohorts, IGF1R RNA expression is significantly associated with the protein abundance of many other proteins, with 14,871 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IGF1R-associated proteins across cancer lineages are FAM98B, MYEF2, and HEXIM1. Each is linked with IGF1R in more than 5 cancer types. Because this analysis shows association rather than direction, both IGF1R-to-partner and partner-to-IGF1R results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGF1R versus FAM98B in BRCA, with a Pearson correlation of 0.37.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IGF1R→partner) and Y-score (partner→IGF1R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FAM98B →	+0.339	+1.457	<.001	<.001	3	6
LSCC	MYEF2 →	+0.689	+0.625	<.001	.007	3	5
GBM	HEXIM1 →	+0.301	+0.529	<.001	.002	3	5
LSCC	IGF1R_T1366 →	+0.603	+0.869	<.001	<.001	3	5
CCRCC	THEMIS2 →	-0.372	-0.897	.001	<.001	3	4
OV	ZNF622_S143 →	-0.768	-1.120	.003	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,871 associations by consensus.

IGF1R vs FAM98B — BRCA

Explore this scatter interactively →