IGF1R

Across TCGA pan-cancer cohorts, IGF1R RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated IGF1R data layer compared with 11 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher IGF1R RNA is associated with better overall survival. In most high-consensus cancer types, elevated IGF1R expression acts as an unfavorable survival marker, although some lineages such as UCS and BRCA show a favorable association.

UCS, BRCA, and KIRC are the cancer types where IGF1R RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	OS	Median	II,III,IV	0.756	0.240	<.001	124	view →
BRCA	OS	Median	All	0.954	0.894	<.001	82	view →
KIRC	OS	Median	All	0.763	0.526	<.001	79	view →
MESO	OS	Tertile	All	0.277	0.531	.001	59	view →
ACC	DFS	Median	All	0.285	0.620	.001	25	view →
COAD	DFS	Median	All	0.739	0.822	.004	24	view →
KIRP	DFS	Median	IV	0.036	0.526	.006	20	view →
SKCM	DFS	Median	All	0.243	0.158	.001	17	view →
DLBC	OS	Median	II,III,IV	1.000	0.303	.013	16	view →
UCEC	DFS	Tertile	All	0.939	0.874	.009	14	view →
BLCA	DFS	Quartile	All	0.215	0.508	.034	13	view →
PAAD	OS	Tertile	II,III,IV	0.630	0.425	.002	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

IGF1R–UCS (OS)

Open the UCS breakdown →