IGF1R

Across TCGA patient cohorts, IGF1R protein abundance is significantly associated with the RNA expression of many other genes, with 16,631 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IGF1R-associated genes across cancer lineages are IRAIN, MIR4714, and LRRC49. Each is linked with IGF1R in more than 6 cancer types. Because this analysis shows association rather than direction, both IGF1R-to-partner and partner-to-IGF1R results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGF1R versus IRAIN in BRCA, with a Pearson correlation of 0.69.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGF1R→partner) and Y-score (partner→IGF1R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	IRAIN →	+1.462	+0.689	<.001	<.001	3	7
LSCC	MIR4714 →	+1.121	+0.801	<.001	<.001	3	7
OV	LRRC49 →	+0.717	+0.513	<.001	.003	3	6
HNSC	INTS14 →	+0.571	+0.446	.001	<.001	3	6
LSCC	C15orf40 →	+0.431	+0.552	<.001	<.001	3	6
CCRCC	EIF3J-DT →	+0.586	+0.556	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,631 associations by consensus.

IGF1R vs IRAIN — BRCA

Explore this scatter interactively →