IGF1R

Across TCGA patient cohorts, IGF1R mutation is significantly associated with the total protein of many other genes, with 67 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGF1R-associated genes across cancer lineages are 4E-BP1, FASN, and p62 Lck ligand. Each is linked with IGF1R in more than 2 cancer types. Because this analysis shows association rather than direction, both IGF1R-to-partner and partner-to-IGF1R results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by IGF1R-low versus IGF1R-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGF1R→partner) and Y-score (partner→IGF1R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.316	+1.509	<.001	<.001	3	3
UCEC	FASN →	+0.275	+1.241	.006	.012	3	3
BLCA	p62 Lck ligand →	+0.448	+3.169	.011	.019	3	2
STAD	Rictor_pT1135 →	-0.149	-2.807	.013	.003	3	2
STAD	YAP_pS127 →	-0.267	-2.115	.036	.017	3	2
STAD	c-Kit →	-0.276	-2.321	.026	.032	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 67 associations by consensus.

4E-BP1 by IGF1R expression — UCEC

Explore this box plot interactively →