IGF1R

Across TCGA cell cohorts, IGF1R RNA expression is significantly associated with the go_rna of many other GO terms, with 4,189 significant associations in total. BONE shows the largest number of these associations.

The most reproducible IGF1R-associated GO terms across cancer lineages are Negative regulation of syncytium formation by plasma membrane fusion, Insulin-like growth factor receptor signaling pathway, and Negative regulation of myoblast fusion. Each is linked with IGF1R in more than 13 cancer types. Because this analysis shows association rather than direction, both IGF1R-to-partner and partner-to-IGF1R results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of syncytium formation by plasma membrane fusion grouped by IGF1R-low versus IGF1R-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGF1R→partner) and Y-score (partner→IGF1R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Negative regulation of syncytium formation by plasma membrane fusion →	+0.145	+0.973	<.001	<.001	3	14
URINARY_TRACT	Insulin-like growth factor receptor signaling pathway →	+0.126	+1.423	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Negative regulation of myoblast fusion →	+0.126	+0.786	<.001	<.001	3	13
BONE	Dendritic spine maintenance →	+0.203	+1.841	<.001	<.001	3	13
STOMACH	Vacuolar transport →	+0.084	+1.975	.006	.001	3	12
BONE	Post-Golgi vesicle-mediated transport →	+0.088	+1.454	<.001	.002	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,189 associations by consensus.

Negative regulation of syncytium formation by plasma membrane fusion by IGF1R expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →