IGF1R

Across TCGA cell cohorts, IGF1R mutation is significantly associated with the RNA expression of many other genes, with 798 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IGF1R-associated genes across cancer lineages are SCRG1, TXNDC15, and SEC24B. Each is linked with IGF1R in more than 1 cancer types. Because this analysis shows association rather than direction, both IGF1R-to-partner and partner-to-IGF1R results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SCRG1 grouped by IGF1R-low versus IGF1R-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGF1R→partner) and Y-score (partner→IGF1R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	SCRG1 →	+0.037	+3.514	.002	.008	3	2
LARGE_INTESTINE	TXNDC15 →	+0.667	+3.502	<.001	.001	3	2
LARGE_INTESTINE	SEC24B →	+0.726	+3.502	<.001	.001	3	2
LARGE_INTESTINE	RSPH10B →	+0.216	+2.537	.003	.008	3	2
LARGE_INTESTINE	MTNR1A →	+0.479	+3.234	<.001	.004	3	2
LARGE_INTESTINE	TNK1 →	+0.807	+3.386	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 798 associations by consensus.

SCRG1 by IGF1R expression — BLOOD_Myeloma

Explore this box plot interactively →