IGF1

Across TCGA patient cohorts, IGF1 protein abundance is significantly associated with the RNA expression of many other genes, with 9,041 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible IGF1-associated genes across cancer lineages are COL3A1, GPIHBP1, and FILIP1. Each is linked with IGF1 in more than 4 cancer types. Because this analysis shows association rather than direction, both IGF1-to-partner and partner-to-IGF1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGF1 versus COL3A1 in GBM, with a Pearson correlation of 0.51.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGF1→partner) and Y-score (partner→IGF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	COL3A1 →	+1.521	+0.371	.006	.004	3	5
CCRCC	GPIHBP1 →	+1.018	+0.401	.003	.004	3	4
CCRCC	FILIP1 →	+0.750	+0.416	<.001	.001	3	4
GBM	INHBA →	+1.959	+0.701	<.001	<.001	3	4
OV	APLNR →	+1.491	+1.163	.001	.004	3	4
BRCA	LRRC4C →	+0.943	+0.662	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,041 associations by consensus.

IGF1 vs COL3A1 — GBM

Explore this scatter interactively →