IGDCC4

Across TCGA cell cohorts, IGDCC4 mutation is significantly associated with the RNA expression of many other genes, with 201 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IGDCC4-associated genes across cancer lineages are MC3R, ADGRE3, and OR5H8. Each is linked with IGDCC4 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGDCC4-to-partner and partner-to-IGDCC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MC3R grouped by IGDCC4-low versus IGDCC4-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGDCC4→partner) and Y-score (partner→IGDCC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	MC3R →	+0.446	+4.108	.009	.005	3	1
LUNG_NSCLC_LUSC	ADGRE3 →	+0.035	+4.584	<.001	.001	3	1
LUNG_NSCLC_LUSC	OR5H8 →	+0.094	+4.108	<.001	.005	3	1
OVARY	ASPN →	+0.031	+2.736	.004	.008	3	1
OVARY	VGLL2 →	+1.390	+3.243	.003	.006	3	1
OVARY	CCDC60 →	+0.032	+2.643	.007	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 201 associations by consensus.

MC3R by IGDCC4 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →