IFT88

Across TCGA patient cohorts, IFT88 mutation is significantly associated with the RNA expression of many other genes, with 3,550 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IFT88-associated genes across cancer lineages are RN7SKP214, TRAJ34, and LINC00709. Each is linked with IFT88 in more than 1 cancer types. Because this analysis shows association rather than direction, both IFT88-to-partner and partner-to-IFT88 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP214 grouped by IFT88-low versus IFT88-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFT88→partner) and Y-score (partner→IFT88) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RN7SKP214 →	+0.480	+3.734	.002	.001	3	2
BRCA	TRAJ34 →	+0.978	+3.809	.001	.009	3	2
COAD	LINC00709 →	+0.075	+4.821	.005	.003	3	2
COAD	RNASEH2CP1 →	+0.244	+3.548	<.001	.002	3	2
COAD	SSX2 →	+0.068	+4.225	<.001	.007	3	2
COAD	TRDV3 →	+0.678	+4.178	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,550 associations by consensus.

RN7SKP214 by IFT88 expression — COAD

Explore this box plot interactively →