IFT80

Across TCGA cell cohorts, IFT80 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible IFT80-associated genes across cancer lineages are CCL25, OR2T4, and SH3GL2. Each is linked with IFT80 in more than 1 cancer types. Because this analysis shows association rather than direction, both IFT80-to-partner and partner-to-IFT80 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCL25 grouped by IFT80-low versus IFT80-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFT80→partner) and Y-score (partner→IFT80) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CCL25 →	+0.092	+4.095	<.001	.009	3	1
SKIN	OR2T4 →	+0.019	+4.415	<.001	.007	3	1
LARGE_INTESTINE	SH3GL2 →	+1.504	+3.252	<.001	.009	3	1
LARGE_INTESTINE	FDCSP →	+0.515	+2.716	.002	.009	3	1
LUNG_NSCLC_LUAD	LILRA4 →	+0.020	+3.149	.008	.002	3	1
LUNG_NSCLC_LUAD	SMIM28 →	+0.022	+3.491	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

CCL25 by IFT80 expression — SKIN

Explore this box plot interactively →