IFT80

Across TCGA pan-cancer cohorts, IFT80 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of IFT80’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where IFT80 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types IFT80 is over-expressed in tumor, although a few such as LUAD and KICH show the opposite, repressed pattern.

BLCA, HNSC, and LIHC are the cancer types where IFT80 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IFT80 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	All	III,IV	+0.818	<.001	10	view →
HNSC	Male	III,IV	+0.823	<.001	9	view →
LIHC	Female	II,III,IV	+0.740	<.001	9	view →
LUAD	All	III,IV	−0.657	<.001	8	view →
KICH	Female	II,III,IV	−1.820	<.001	7	view →
CHOL	All	All	+2.512	<.001	5	view →
STAD	All	II,III,IV	+0.632	.005	5	view →
COAD	Male	All	+0.445	<.001	4	view →
BRCA	All	II,III,IV	+0.254	.003	4	view →
THCA	All	II,III,IV	−0.266	.024	2	view →
LUSC	All	III,IV	−0.743	.031	1	view →
ESCA	All	All	+0.591	.016	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

IFT80–BLCA

Open the BLCA breakdown →