IFT80

Across TCGA cell cohorts, IFT80 mutation is significantly associated with the mutation status of many other genes, with 4,622 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IFT80-associated genes across cancer lineages are SCN11A, SAMD9, and FCGBP. Each is linked with IFT80 in more than 3 cancer types. Because this analysis shows association rather than direction, both IFT80-to-partner and partner-to-IFT80 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SCN11A grouped by IFT80-low versus IFT80-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFT80→partner) and Y-score (partner→IFT80) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	SCN11A →	+4.862	+4.862	<.001	<.001	1	4
CNS	SAMD9 →	+4.277	+4.584	.001	.001	1	4
LUNG_NSCLC_LUAD	FCGBP →	+2.151	+3.381	.001	.001	1	4
BLOOD_Leukemia	MYO9A →	+2.473	+4.280	.002	.002	1	4
STOMACH	MDC1 →	+4.807	+4.807	.008	.008	1	4
STOMACH	AK7 →	+4.807	+4.807	.008	.008	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,622 associations by consensus.

SCN11A by IFT80 expression — CNS

Explore this box plot interactively →