IFT74

Across TCGA pan-cancer cohorts, IFT74 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated IFT74 data layer compared with 26 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher IFT74 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated IFT74 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

MESO, SKCM, and UCS are the cancer types where IFT74 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	II,III,IV	0.071	0.572	<.001	24	view →
SKCM	OS	Median	All	0.374	0.790	<.001	15	view →
UCS	OS	Median	All	0.153	0.687	.019	6	view →
UCEC	DFS	Median	All	0.959	0.625	.022	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

IFT74–MESO (OS)

Open the MESO breakdown →