IFT74

Across TCGA pan-cancer cohorts, IFT74 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of IFT74’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where IFT74 RNA is repressed in tumor relative to normal tissue. In most cancer types IFT74 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

KICH, KIRC, and THCA are the cancer types where IFT74 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IFT74 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−2.101	<.001	11	view →
KIRC	Male	III,IV	−0.595	<.001	11	view →
THCA	Male	III,IV	−0.769	<.001	10	view →
LIHC	All	II,III,IV	+0.621	<.001	8	view →
CHOL	All	All	+1.443	<.001	4	view →
COAD	Female	All	−0.558	.045	2	view →
UCEC	All	All	−0.410	.041	2	view →
KIRP	All	All	−0.333	.033	2	view →
ESCA	Female	All	+0.620	.028	1	view →
LUSC	Male	All	−0.384	.019	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

IFT74–KICH

Open the KICH breakdown →