IFT74

Across TCGA pan-cancer cohorts, IFT74 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated IFT74 data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher IFT74 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated IFT74 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

LSCC, GBM, and PDAC are the cancer types where IFT74 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	II,III,IV	0.876	1.000	.005	15	view →
GBM	OS	Quartile	All	0.703	0.916	.006	8	view →
PDAC	DFS	Quartile	III,IV	0.411	0.837	.011	6	view →
UCEC	OS	Median	II,III,IV	0.620	1.000	.011	4	view →
CCRCC	OS	Quartile	All	1.000	0.664	.034	4	view →
LUAD	OS	Tertile	All	1.000	0.955	.038	3	view →
HNSC	OS	Quartile	All	0.576	0.798	.029	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

IFT74–LSCC (DFS)

Open the LSCC breakdown →