IFT74

Across TCGA patient cohorts, IFT74 mutation is significantly associated with the RNA expression of many other genes, with 2,260 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IFT74-associated genes across cancer lineages are DPP4-DT, TRAV1-1, and RNU7-28P. Each is linked with IFT74 in more than 1 cancer types. Because this analysis shows association rather than direction, both IFT74-to-partner and partner-to-IFT74 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DPP4-DT grouped by IFT74-low versus IFT74-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFT74→partner) and Y-score (partner→IFT74) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DPP4-DT →	+0.253	+1.913	.007	.002	3	2
UCEC	TRAV1-1 →	+0.389	+2.447	<.001	<.001	3	2
LUAD	RNU7-28P →	+0.711	+5.473	.001	<.001	3	2
LUSC	TIPINP1 →	+0.123	+3.241	<.001	.005	3	2
LUSC	H4P1 →	+0.115	+3.900	.004	.001	3	2
LUSC	MIR4710 →	+0.446	+3.922	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,260 associations by consensus.

DPP4-DT by IFT74 expression — UCEC

Explore this box plot interactively →