IFT74

Across TCGA cell cohorts, IFT74 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IFT74-associated genes across cancer lineages are MYMK, TPD52L3, and TFDP3. Each is linked with IFT74 in more than 1 cancer types. Because this analysis shows association rather than direction, both IFT74-to-partner and partner-to-IFT74 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYMK grouped by IFT74-low versus IFT74-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFT74→partner) and Y-score (partner→IFT74) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MYMK →	+0.027	+4.922	<.001	.009	3	1
LARGE_INTESTINE	TPD52L3 →	+0.044	+3.684	<.001	.006	3	1
LARGE_INTESTINE	TFDP3 →	+0.024	+4.196	<.001	.002	3	1
LARGE_INTESTINE	NEXMIF →	+0.340	+4.196	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

MYMK by IFT74 expression — BLOOD_Leukemia

Explore this box plot interactively →