IFT74-AS1

Across TCGA pan-cancer cohorts, IFT74-AS1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated IFT74-AS1 data layer.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher IFT74-AS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated IFT74-AS1 expression acts as an unfavorable survival marker, although some lineages such as LUSC and OV show a favorable association.

LUSC, ACC, and OV are the cancer types where IFT74-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Median	All	0.735	0.612	<.001	44	view →
ACC	DFS	Median	II,III,IV	0.554	0.864	.005	41	view →
OV	OS	Quartile	III,IV	0.770	0.604	.004	36	view →
KIRC	DFS	Median	IV	0.219	0.496	.001	36	view →
HNSC	DFS	Median	All	0.541	0.641	.007	33	view →
MESO	DFS	Tertile	II,III,IV	0.396	0.211	.011	28	view →
CESC	OS	Quartile	III,IV	0.185	0.648	.016	28	view →
UVM	OS	Median	III,IV	0.252	0.836	.005	27	view →
READ	DFS	Median	II,III,IV	0.909	0.628	.007	26	view →
COAD	DFS	Median	All	0.628	0.746	.008	20	view →
THYM	DFS	Tertile	III,IV	0.601	0.932	.001	15	view →
LUAD	OS	Median	All	0.764	0.631	.007	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

IFT74-AS1–LUSC (OS)

Open the LUSC breakdown →