IFT74-AS1

Across TCGA pan-cancer cohorts, IFT74-AS1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of IFT74-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where IFT74-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types IFT74-AS1 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

KICH, KIRC, and THCA are the cancer types where IFT74-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IFT74-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−1.035	<.001	11	view →
KIRC	Male	II,III,IV	−0.428	<.001	10	view →
THCA	Male	All	−0.503	<.001	6	view →
LIHC	Male	All	+0.269	<.001	5	view →
BRCA	All	All	−0.116	.002	4	view →
BLCA	All	III,IV	+0.211	.033	3	view →
KIRP	All	IV	−0.410	.033	2	view →
PAAD	Male	All	+0.290	.018	2	view →
UCEC	All	All	−0.231	.029	2	view →
COAD	All	III,IV	+0.198	.016	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

IFT74-AS1–KICH

Open the KICH breakdown →