IFT57

Across TCGA pan-cancer cohorts, IFT57 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated IFT57 data layer compared with 24 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher IFT57 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated IFT57 expression acts as an unfavorable survival marker.

LIHC, LUSC, and SKCM are the cancer types where IFT57 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	DFS	Median	II,III,IV	0.030	0.430	<.001	12	view →
LUSC	DFS	Median	All	0.165	0.707	.046	3	view →
SKCM	DFS	Median	III,IV	0.063	0.648	.003	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

IFT57–LIHC (DFS)

Open the LIHC breakdown →