IFT57

Across TCGA cell cohorts, IFT57 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IFT57-associated genes across cancer lineages are GSG1L2, C6orf118, and DEFA4. Each is linked with IFT57 in more than 1 cancer types. Because this analysis shows association rather than direction, both IFT57-to-partner and partner-to-IFT57 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSG1L2 grouped by IFT57-low versus IFT57-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFT57→partner) and Y-score (partner→IFT57) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GSG1L2 →	+0.058	+5.969	<.001	.001	3	2
LARGE_INTESTINE	C6orf118 →	+0.173	+4.115	<.001	.001	3	1
LARGE_INTESTINE	DEFA4 →	+0.026	+4.022	<.001	.006	3	1
LARGE_INTESTINE	OR6Q1 →	+0.015	+4.022	<.001	.006	3	1
BLOOD_Leukemia	OR51T1 →	+0.071	+4.922	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

GSG1L2 by IFT57 expression — BLOOD_Leukemia

Explore this box plot interactively →