IFT52

Across TCGA patient cohorts, IFT52 mutation is significantly associated with the RNA expression of many other genes, with 975 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IFT52-associated genes across cancer lineages are RNU6-1213P, XAGE1A, and RNU6-763P. Each is linked with IFT52 in more than 3 cancer types. Because this analysis shows association rather than direction, both IFT52-to-partner and partner-to-IFT52 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1213P grouped by IFT52-low versus IFT52-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFT52→partner) and Y-score (partner→IFT52) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-1213P →	+0.181	+3.555	<.001	.002	3	4
SARC	XAGE1A →	+0.203	+5.477	<.001	.004	3	3
SKCM	RNU6-763P →	+0.263	+5.900	<.001	<.001	3	2
SKCM	RAB1AP2 →	+0.053	+4.614	<.001	.006	3	2
SKCM	RN7SL440P →	+0.128	+4.163	<.001	.003	3	2
LUSC	ATF4P1 →	+0.068	+3.416	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 975 associations by consensus.

RNU6-1213P by IFT52 expression — UCEC

Explore this box plot interactively →